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Ibuprofen Intravenous and Zidovudine Injection

Determining the interaction of Ibuprofen Intravenous and Zidovudine Injection and the possibility of their joint administration.

Check result:

Ibuprofen Intravenous <> Zidovudine Injection

Relevance: 28.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using zidovudine together with ibuprofen may increase the risk of bleeding in HIV-positive patients with hemophilia. However, the interaction is not fully understood, and evidence is limited. Talk to your doctor or pharmacist if you have any concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Limited clinical data suggest that the concomitant use of zidovudine with nonsteroidal anti-inflammatory agents may increase the risk of hematological toxicity and/or bleeding in HIV-positive patients with hemophilia. The mechanism is unknown.

MANAGEMENT: It is recommended to monitor patients for side effects and bleeding during concomitant use.

References

Cerner Multum, Inc. "Australian Product Information." O 0
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Sim SM, Back DJ, Breckenridge AM "The effect of various drugs on the glucuronidation of zidovudine (azidothymidine; AZT) by human liver microsomes." Br J Clin Pharmacol 32 (1991): 17-21
Sahai J, Gallicano K, Conway B, et al. "Lack of pharmacokinetic interaction between naproxen (N) and zidovudine (Z)." Clin Pharmacol Ther 51 (1992): 184
Sahai J, Gallicano K, Garber G, et al. "Evaluation of the in vivo effect of naproxen on zidovudine pharmacokinetics in patients infected with human immunodeficiency virus." Clin Pharmacol Ther 52 (1992): 464-70
Burger DM, Meenhorst PL, Koks CH, Beijnen JH "Drug interactions with zidovudine." AIDS 7 (1993): 445-60

Ibuprofen Intravenous

Generic Name: ibuprofen

Brand name: Advil, Midol, Motrin, Motrin IB, Motrin Migraine Pain, Proprinal, Smart Sense Children's Ibuprofen, PediaCare Children’s Pain Reliever/Fever Reducer, PediaCare Infant’s Pain Reliever/Fever Reducer, Advil Liqui-Gels, Caldolor, NeoProfen, Genpril, Ibu, Midol IB, Children's Motrin, Motrin Junior Strength

Synonyms: Ibuprofen

What is Ibuprofen Intravenous?

Zidovudine Injection

Generic Name: zidovudine

Brand name: Retrovir

Synonyms: Zidovudine (oral/injection), Zidovudine

What is Zidovudine Injection?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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