Ifex/Mesnex Kit and Modafinil
Determining the interaction of Ifex/Mesnex Kit and Modafinil and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:The concomitant use of modafinil may theoretically alter the metabolic activation and inactivation of ifosfamide and cyclophosphamide. Modafinil is a modest CYP450 2B6 and 3A4 inducer in vitro. Ifosfamide and cyclophosphamide are substrates of these isoenzymes. If these drugs are to be used together, close monitoring of the patient for altered efficacy and safety is recommended.
- Robertson P, Decory HH, Madan A, Parkinson A "In vitro inhibition and induction of human hepatic cytochrome P450 enzymes by modafinil." Drug Metab Dispos 28 (2000): 664-71
- "Product Information. Provigil (modafinil)." Cephalon, Inc, West Chester, PA.
Generic Name: ifosfamide
Brand name: Ifex
Synonyms: Ifosfamide
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Ifex/Mesnex Kit-Moderiba
- Ifex/Mesnex Kit-Moduretic 5-50
- Ifex/Mesnex Kit-Moexipril
- Ifex/Mesnex Kit-Moexipril and Hydrochlorothiazide
- Ifex/Mesnex Kit-Moexipril Hydrochloride
- Ifex/Mesnex Kit-Mogamulizumab
- Modafinil-Ifosfamide
- Modafinil-Ifosfamide and Mesna Injection
- Modafinil-Ifosfamide Intravenous
- Modafinil-Ilaris
- Modafinil-Ilevro
- Modafinil-Iloperidone