Ifex/Mesnex Kit and Skyla

• Generic Name: ifosfamide
• Dosage Forms: n.a.
• Other Brand Names: Ifex

Component of various chemotherapeutic regimens as third-line therapy for recurrent or refractory germ cell testicular cancer (designated an orphan drug by FDA for this use).

Component of various chemotherapeutic regimens in conjunction with surgery and/or radiation therapy in the treatment of various soft tissue sarcomas (designated an orphan drug by FDA for this use).

Used alone or in conjunction with other drugs (e.g., etoposide) for treatment of localized, metastatic, and recurrent osteosarcoma (designated an orphan drug by FDA for this use).

Used alone or in combination with other antineoplastic agents for treatment of advanced or metastatic bladder cancer.

Treatment of small cell lung cancer as part of a combination regimen.

Component of various combination regimens (e.g., cisplatin and ifosfamide with or without bleomycin) for the treatment of metastatic or recurrent cervical cancer.

Used alone or in conjunction with other antineoplastic agents for second-line (salvage) therapy in patients with advanced or recurrent ovarian carcinoma.

Treatment of advanced small noncleaved cell lymphoma (Burkitt’s and non-Burkitt’s) in children as part of a combination regimen.

• Generic Name: levonorgestrel
• Dosage Forms: intrauterine device
• Other Brand Names: Skyla, Kyleena, Liletta, Mirena, Aftera, EContra EZ, EContra One-Step, Fallback Solo, My Choice, My Way, New Day, Next Choice One Dose, Opcicon One-Step, Plan B One-Step, React, Take Action, My Way, Next Choice

Skyla contains levonorgestrel, a female hormone that can cause changes in your cervical mucus and uterine lining, making it harder for sperm to reach the uterus and harder for a fertilized egg to attach to the uterus.

Skyla intrauterine device (IUD) is a small, flexible plastic T-shaped device. This device is placed in the uterus where it slowly releases the hormone to prevent pregnancy for 3 years. (Other types of levonorgestrel intrauterine systems release different amounts of hormone and are used for different lengths of time.)

Skyla can be used whether you have had children or not. It should not be used during pregnancy.

Levonorgestrel is a progestin hormone and does not contain estrogen. The Skyla IUD releases levonorgestrel in the uterus, but only small amounts of the hormone reach the bloodstream. Skyla should not be used as emergency birth control.