Ifosfamide and Mesna Injection and Leukine (Sargramostim Solution for Injection)
Determining the interaction of Ifosfamide and Mesna Injection and Leukine (Sargramostim Solution for Injection) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using sargramostim during or too soon after completion of a course of ifosfamide may alter the effects of either medication. Sargramostim should generally not be given within 24 hours before or 24 hours after cancer chemotherapy. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSING INTERVAL: The safety and efficacy of hematopoietic growth factors such as colony-stimulating factors (G-CSF and GM-CSF) and stem cell factors (SCF) given simultaneously with cancer chemotherapy have not been established. Theoretical concerns exist regarding their concomitant administration because hematopoietic growth factors stimulate myeloid cell proliferation while antineoplastic agents primarily target rapidly dividing cells.
MANAGEMENT: Because of the potential sensitivity of rapidly dividing myeloid cells to cancer chemotherapy, hematopoietic growth factors should not be used within 24 hours before or 24 hours after administration of antineoplastic agents.
- "Product Information. Leukine (sargramostim)." Immunex Corporation, Seattle, WA.
- "Product Information. Granix (tbo-filgrastim)." Teva Pharmaceuticals USA, North Wales, PA.
- "Product Information. Stemgen (ancestim)" Amgen, Thousand Oaks, CA.
- "Product Information. Neupogen (filgrastim)." Amgen, Thousand Oaks, CA.
Generic Name: ifosfamide / mesna
Brand name:
Synonyms: n.a.
Generic Name: sargramostim
Brand name: Leukine
Synonyms: Leukine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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- Ifosfamide and Mesna Injection-Leuprolide Injection (CPP)
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