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Imatinib and Prevacid

Determining the interaction of Imatinib and Prevacid and the possibility of their joint administration.

Check result:

Imatinib <> Prevacid

Relevance: 21.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Imatinib may increase the blood levels and side effects of lansoprazole. Contact your doctor if you experience diarrhea or other intestinal problems. You may need a dose adjustment if you take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Theoretically, coadministration with imatinib may increase the plasma concentrations of lansoprazole. The proposed mechanism is imatinib inhibition of lansoprazole metabolism via CYP450 2C9 and 3A4. There has also been a reported case of a patient with gastrointestinal stromal tumors who developed severe cutaneous adverse reactions during treatment with imatinib and lansoprazole. The patient had been receiving imatinib 400 mg/day alone for two months without incident. Ten days after lansoprazole 15 mg/day was added for dyspepsia, the patient exhibited bilateral palpebral edema with hyperemic conjunctivae and labial edema. The drugs were immediately withdrawn and were restarted five days later, whereupon the symptoms reappeared promptly within 24 hours. The patient was treated with a piperazine antihistamine but subsequently developed mucocutaneous lesions that led to her hospitalization with a diagnosis of Stevens-Johnson syndrome. The patient recovered following discontinuation of the drugs and treatment with methylprednisolone and desloratadine for 30 days. A reintroduction of imatinib at 300 mg/day, along with methylprednisolone and desloratadine, resulted in a third episode of cutaneous adverse reactions when the patient failed to inform her physicians that she had taken a dose of lansoprazole the day before. The drugs were withdrawn and the patient once again recovered. The mechanism of this potential interaction is unknown, but involvement of CYP450 3A4 metabolism is suspected.

MANAGEMENT: Until more data are available, caution is advised if imatinib must be used in combination with lansoprazole.

References

"Product Information. Gleevec (imatinib mesylate)." Novartis Pharmaceuticals, East Hanover, NJ.
"Product Information. Prevacid (lansoprazole)." TAP Pharmaceuticals Inc, Deerfield, IL.
Katsuki H, Hamada A, Nakamura C, Arimori K, Nakano M "Role of CYP3A4 and CYP2C19 in the stereoselective metabolism of lansoprazole by human liver microsomes." Eur J Clin Pharmacol 57 (2001): 709-15
Severino G, Chillotti C, De Lisa R, Del Zompo M, Ardau R "Adverse reactions during imatinib and lansoprazole treatment in gastrointestinal stromal tumors." Ann Pharmacother 39 (2005): 162-4

Imatinib

Generic Name: imatinib

Brand name: Gleevec

Synonyms: n.a.

What is Imatinib?

Prevacid

Generic Name: lansoprazole

Brand name: FIRST Lansoprazole, Prevacid, Prevacid OTC, Prevacid SoluTab

Synonyms: n.a.

What is Prevacid?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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