Imatinib Mesylate and Naproxen and Diphenhydramine
Determining the interaction of Imatinib Mesylate and Naproxen and Diphenhydramine and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Imatinib may increase the blood levels and effects of naproxen. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with imatinib may increase the plasma concentrations of drugs that are substrates of CYP450 2C9, 2D6 and/or 3A4. The mechanism is decreased clearance due to inhibition of these isoenzymes by imatinib. According to the manufacturer, imatinib increased the mean peak plasma concentration (Cmax) and systemic exposure (AUC) of simvastatin, a sensitive CYP450 3A4 substrate, by 2- and 3.5-fold, respectively. Data for other substrates are limited, although human liver microsome studies indicate that imatinib is a potent competitive inhibitor of all three isoenzymes.
MANAGEMENT: Caution is advised when imatinib is used concomitantly with drugs that undergo metabolism by CYP450 2C9, 2D6 and/or 3A4, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever imatinib is added to or withdrawn from therapy.
- "Product Information. Gleevec (imatinib mesylate)." Novartis Pharmaceuticals, East Hanover, NJ.
Generic Name: imatinib
Brand name: Gleevec
Synonyms: Imatinib
Generic Name: diphenhydramine / naproxen
Brand name:
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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- Imatinib Mesylate-Naproxen Modified-Release Tablets
- Imatinib Mesylate-Naproxen Sodium
- Naproxen and Diphenhydramine-Imbruvica
- Naproxen and Diphenhydramine-Imbruvica (Ibrutinib Capsules)
- Naproxen and Diphenhydramine-Imbruvica (Ibrutinib Tablets)
- Naproxen and Diphenhydramine-Imdur
- Naproxen and Diphenhydramine-Imdur ER
- Naproxen and Diphenhydramine-Imfinzi