Imatinib Mesylate and Rifampin Injection
Determining the interaction of Imatinib Mesylate and Rifampin Injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Ask your doctor before using rifAMPin together with imatinib. RifAMPin may decrease the effects of imatinib. Contact your doctor if your condition worsens. If your doctor prescribes these medications together, you may need a dose adjustment to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration with rifampin may significantly decrease the plasma concentrations of imatinib. The mechanism is rifampin induction of CYP450 3A4, the isoenzyme responsible for the metabolic clearance of imatinib. In 14 healthy volunteers, pretreatment with rifampin (600 mg orally once daily for 10 days) decreased the mean peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of imatinib (400 mg single oral dose) by 54% and 74%, respectively, compared to administration of imatinib alone. The clearance was increased 385% during rifampin coadministration. Although the pharmacokinetics of imatinib were subject to a high degree of intersubject variation, the interaction was reported in every subject.
MANAGEMENT: Due to the magnitude of the interaction that can potentially result in subtherapeutic plasma concentrations of imatinib, concomitant use with rifampin should be avoided if possible.
- "Product Information. Gleevec (imatinib mesylate)." Novartis Pharmaceuticals, East Hanover, NJ.
- Bolton AE, Peng B, Hubert M, et al. "Effect of rifampicin on the pharmacokinetics of imatinib mesylate (Gleevec, STI571) in healthy subjects." Cancer Chemother Pharmacol 53 (2004): 102-6
Generic Name: imatinib
Brand name: Gleevec
Synonyms: Imatinib
Generic Name: rifampin
Brand name: Rifadin, Rifadin IV, Rimactane
Synonyms: Rifampin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Imatinib Mesylate-Rifampin Intravenous
- Imatinib Mesylate-Rifampin Oral, Intravenous
- Imatinib Mesylate-Rifampin, Isoniazid, and Pyrazinamide
- Imatinib Mesylate-Rifamycin
- Imatinib Mesylate-Rifamycin Sodium
- Imatinib Mesylate-Rifapentine
- Rifampin Injection-Imbruvica
- Rifampin Injection-Imbruvica (Ibrutinib Capsules)
- Rifampin Injection-Imbruvica (Ibrutinib Tablets)
- Rifampin Injection-Imdur
- Rifampin Injection-Imdur ER
- Rifampin Injection-Imfinzi