Imatinib Mesylate and Trileptal (Oxcarbazepine Oral Suspension)
Determining the interaction of Imatinib Mesylate and Trileptal (Oxcarbazepine Oral Suspension) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:OXcarbazepine may reduce the blood levels and effects of imatinib. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration with drugs that are inducers of CYP450 3A4 may decrease the plasma concentrations of imatinib, which is primarily metabolized by the isoenzyme. The possibility of a diminished therapeutic response to imatinib should be considered, particularly during concomitant therapy with potent 3A4 inducers such as rifampin or carbamazepine.
MANAGEMENT: Concomitant use with imatinib and strong CYP450 3A4 inducers should be avoided, if clinically feasible. If coadministration cannot be avoided, it is recommended to increase the dosage of imatinib by at least 50% and monitor the patient's clinical response.
- "Product Information. Gleevec (imatinib mesylate)." Novartis Pharmaceuticals, East Hanover, NJ.
- Bolton AE, Peng B, Hubert M, et al. "Effect of rifampicin on the pharmacokinetics of imatinib mesylate (Gleevec, STI571) in healthy subjects." Cancer Chemother Pharmacol 53 (2004): 102-6
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
- Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."
- EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports. Available from: URL: http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landingpage.jsp&mid."
Generic Name: imatinib
Brand name: Gleevec
Synonyms: Imatinib
Generic Name: oxcarbazepine
Brand name: Oxtellar XR, Trileptal
Synonyms: Trileptal
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Imatinib Mesylate-Trileptal (Oxcarbazepine Tablets)
- Imatinib Mesylate-Trilipix
- Imatinib Mesylate-Trilisate
- Imatinib Mesylate-Triloan II SUIK
- Imatinib Mesylate-Triloan SUIK
- Imatinib Mesylate-TriLyte
- Trileptal (Oxcarbazepine Oral Suspension)-Imbruvica
- Trileptal (Oxcarbazepine Oral Suspension)-Imbruvica (Ibrutinib Capsules)
- Trileptal (Oxcarbazepine Oral Suspension)-Imbruvica (Ibrutinib Tablets)
- Trileptal (Oxcarbazepine Oral Suspension)-Imdur
- Trileptal (Oxcarbazepine Oral Suspension)-Imdur ER
- Trileptal (Oxcarbazepine Oral Suspension)-Imfinzi