Imatinib Mesylate and Viramune O/S
Determining the interaction of Imatinib Mesylate and Viramune O/S and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using imatinib together with nevirapine can alter the blood levels and effects of both medications. Specifically, imatinib levels may decrease, which may make the medication less effective. At the same time, nevirapine levels may increase. Contact your doctor if your condition changes or you experience increased side effects. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Imatinib is a substrate as well as a potent competitive inhibitor of the CYP450 3A4 enzymatic pathway. Theoretically, pharmacokinetic interactions may occur during the coadministration of imatinib with drugs that act as both inducer and substrate of the metabolic pathway. However, data are currently insufficient to predict the potential consequences and clinical significance of such interactions.
MANAGEMENT: During concomitant therapy, the possibility of a diminished therapeutic response to imatinib should be considered. In addition, clinical and laboratory monitoring for potentially increased pharmacologic effects of concomitantly administered medications, particularly those with a narrow therapeutic range, may be appropriate.
- "Product Information. Gleevec (imatinib mesylate)." Novartis Pharmaceuticals, East Hanover, NJ.
Generic Name: imatinib
Brand name: Gleevec
Synonyms: Imatinib
Generic Name: nevirapine
Brand name: Viramune, Viramune XR
Synonyms: Nevirapine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Imatinib Mesylate-Viramune Suspension
- Imatinib Mesylate-Viramune XR
- Imatinib Mesylate-Virasal
- Imatinib Mesylate-Virasal Topical
- Imatinib Mesylate-Viravan P
- Imatinib Mesylate-Viravan PDM
- Viramune O/S-Imbruvica
- Viramune O/S-Imbruvica (Ibrutinib Capsules)
- Viramune O/S-Imbruvica (Ibrutinib Tablets)
- Viramune O/S-Imdur
- Viramune O/S-Imdur ER
- Viramune O/S-Imfinzi