Imatinib Mesylate and Zoloft (Sertraline Oral Liquid)
Determining the interaction of Imatinib Mesylate and Zoloft (Sertraline Oral Liquid) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using imatinib together with sertraline may increase the blood levels and effects of both medications. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Imatinib is a substrate of the CYP450 3A4 isoenzyme as well as a potent competitive inhibitor of the CYP450 2C9, 2D6 and 3A4 isoenzymes. Some drugs that are known inhibitors of CYP450 3A4 are also metabolized by one or more of the isoenzymes inhibited by imatinib. Theoretically, coadministration of imatinib with those drugs may result in mutually elevated plasma drug concentrations due to competitive and noncompetitive inhibition of CYP450 activities.
MANAGEMENT: The possibility of prolonged and/or increased pharmacologic effects of imatinib, including serious adverse effects such as edema, hematologic toxicity and immunosuppression, should be considered during concomitant therapy, particularly with potent CYP450 3A4 inhibitors such as ketoconazole, itraconazole, ritonavir, nefazodone, and erythromycin. In addition, clinical and laboratory monitoring for potentially increased pharmacologic effects of coadministered medications is recommended, especially those with a narrow therapeutic range.
- "Product Information. Gleevec (imatinib mesylate)." Novartis Pharmaceuticals, East Hanover, NJ.
Generic Name: imatinib
Brand name: Gleevec
Synonyms: Imatinib
Generic Name: sertraline
Brand name: Zoloft
Synonyms: Zoloft
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Imatinib Mesylate-Zoloft (Sertraline Tablets)
- Imatinib Mesylate-Zolpidem
- Imatinib Mesylate-Zolpidem Extended Release
- Imatinib Mesylate-Zolpidem Extended-Release Tablets
- Imatinib Mesylate-Zolpidem Oral Spray
- Imatinib Mesylate-Zolpidem Oral, Oromucosal
- Zoloft (Sertraline Oral Liquid)-Imbruvica
- Zoloft (Sertraline Oral Liquid)-Imbruvica (Ibrutinib Capsules)
- Zoloft (Sertraline Oral Liquid)-Imbruvica (Ibrutinib Tablets)
- Zoloft (Sertraline Oral Liquid)-Imdur
- Zoloft (Sertraline Oral Liquid)-Imdur ER
- Zoloft (Sertraline Oral Liquid)-Imfinzi