Imbruvica (Ibrutinib Tablets) and Tegretol

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Talk to your doctor before using ibrutinib together with carBAMazepine. Combining these medications may significantly reduce the blood levels of ibrutinib, which may decrease its effectiveness in treating your condition. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with inducers of CYP450 3A4 may significantly decrease the plasma concentrations of ibrutinib, which is primarily metabolized by the isoenzyme. Preliminary pharmacokinetic data from an ongoing dedicated drug interaction trial and simulations using physiologically based pharmacokinetic models indicate that rifampin, a potent CYP450 3A4 inducer, can decrease ibrutinib peak plasma concentration (Cmax) and systemic exposure (AUC) by more than 10-fold. Pharmacokinetic modeling also suggests that a moderate CYP450 3A4 inducer such as efavirenz may decrease the AUC of ibrutinib up to 3-fold.

MANAGEMENT: The use of ibrutinib in combination with potent CYP450 3A4 inducers such as carbamazepine, enzalutamide, phenobarbital, phenytoin, and rifamycins should generally be avoided.

Imbruvica (Ibrutinib Tablets)

Generic Name: ibrutinib

Brand name: Imbruvica

Synonyms: Imbruvica

What is Imbruvica (Ibrutinib Tablets)?

Tegretol

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: n.a.

What is Tegretol?