Imiglucerase Intravenous and Zavesca

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ask your doctor before using imiglucerase together with miglustat. Using these medications together can decrease the effects of imiglucerase. Contact your doctor if your condition worsens. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with miglustat may increase the clearance of imiglucerase. The mechanism of interaction has not been described. In patients stabilized on imiglucerase 7.5 or 15 units/kg/day, coadministration with miglustat 100 mg orally three times a day for one month appeared to increase the clearance of imiglucerase by 70%, although the results are not conclusive due to the small number of subjects studied and the variable doses of imiglucerase administered. Imiglucerase had no significant effect on the pharmacokinetics of miglustat.

MANAGEMENT: Miglustat labeling states that use with imiglucerase is not indicated.

Imiglucerase Intravenous

Generic Name: imiglucerase

Brand name: Cerezyme

Synonyms: Imiglucerase

What is Imiglucerase Intravenous?

Zavesca

Generic Name: miglustat

Brand name: Zavesca

Synonyms: n.a.

What is Zavesca?