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Imipenem and cilastatin and Neoral

Determining the interaction of Imipenem and cilastatin and Neoral and the possibility of their joint administration.

Check result:

Imipenem and cilastatin <> Neoral

Relevance: 23.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using cycloSPORINE together with imipenem may cause nerve loss. Tell your doctor if you experience confusion, dizziness, numbness, skin tingling, muscle twitching, or seizures which may be signs of nerve damage. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Limited data suggest that the neurotoxic effects of imipenem and cyclosporine may be additive. The mechanism is unknown but may be due to additive CNS effects.

MANAGEMENT: Until more data are available, patients should be monitored for altered cyclosporine concentrations and CNS toxicity (e.g., tremor, agitation, confusion, aphasia).

References

Zazgornik J, Schein W, Heimberger K, et al "Potentiation of neurotoxic side effects by coadministration of imipenem to cyclosporine therapy in a kidney transplant recipient: synergism of side effects or drug." Clin Nephrol 26 (1986): 265-6
Cockburn IT, Krupp P "An appraisal of drug interactions with sandimmun." Transplant Proc 21 (1989): 3845-50
Bosmuller C, Steurer W, Konigsrainer A, et al "Increased risk of central nervous system toxicity in patients treated with ciclosporin and imipenem/cilastatin." Nephron 58 (1991): 362-4

Imipenem and cilastatin

Generic Name: cilastatin / imipenem

Brand name: Primaxin IV, Primaxin IM, Primaxin IV ADD-Vantage

Synonyms: Imipenem and Cilastatin

What is Imipenem and cilastatin?

Neoral

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Neoral (Capsules, Modified)

What is Neoral?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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