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Imipenem and Cilastatin Injection and Theo-Dur

Determining the interaction of Imipenem and Cilastatin Injection and Theo-Dur and the possibility of their joint administration.

Check result:

Imipenem and Cilastatin Injection <> Theo-Dur

Relevance: 08.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using theophylline together with imipenem may cause seizures. Contact your doctor if you experience confusion, seizures, and other mental status changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Some case reports suggest an increased risk of seizures when theophylline and imipenem are coadministered. The mechanism is unknown. Patients receiving large doses of either drug and/or with renal dysfunction may be at a higher risk.

MANAGEMENT: Dosing should be individualized and patients should be closely monitored for signs of neurotoxicity (e.g., confusion, seizures, myoclonic activity).

References

Semel JD, Allen N "Seizures in patients simultaneously receiving theophylline and imipenem or ciprofloxacin or metronidazole." South Med J 84 (1991): 465-8

Imipenem and Cilastatin Injection

Generic Name: cilastatin / imipenem

Brand name: Primaxin IV, Primaxin IM, Primaxin IV ADD-Vantage

Synonyms: Imipenem and cilastatin, Imipenem and Cilastatin

What is Imipenem and Cilastatin Injection?

Theo-Dur

Generic Name: theophylline

Brand name: Elixophyllin, Theo-24, Respbid, T-Phyl, Aerolate III, Slo-Bid Gyrocaps, Slo-Phyllin, Theobid, Theo-Dur, Theolair, Theovent, Bronkodyl, Theo-X, Theo-Time, Theochron, Slo-Phyllin 125, Theoclear LA-130, Aerolate JR, Theolair-SR, Theoclear LA-260, Quibron-T, Quibron-T/SR, Uniphyl, Uni-Dur, Aerolate SR, Slo-Phyllin 80, Theoclear-80, Theo-Dur Sprinkles, Theosol-80, Asmalix, Aquaphyllin, Truxophyllin, Slo-Phyllin 250, TheoCap

Synonyms: Theo-Dur (Oral)

What is Theo-Dur?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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