Imipenem and Cilastatin Injection and Theophylline in Dextrose
Determining the interaction of Imipenem and Cilastatin Injection and Theophylline in Dextrose and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using theophylline together with imipenem may cause seizures. Contact your doctor if you experience confusion, seizures, and other mental status changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Some case reports suggest an increased risk of seizures when theophylline and imipenem are coadministered. The mechanism is unknown. Patients receiving large doses of either drug and/or with renal dysfunction may be at a higher risk.
MANAGEMENT: Dosing should be individualized and patients should be closely monitored for signs of neurotoxicity (e.g., confusion, seizures, myoclonic activity).
- Semel JD, Allen N "Seizures in patients simultaneously receiving theophylline and imipenem or ciprofloxacin or metronidazole." South Med J 84 (1991): 465-8
Generic Name: cilastatin / imipenem
Brand name: Primaxin IV, Primaxin IM, Primaxin IV ADD-Vantage
Synonyms: Imipenem and cilastatin, Imipenem and Cilastatin
Generic Name: theophylline
Brand name: Elixophyllin, Theo-24, Respbid, T-Phyl, Aerolate III, Slo-Bid Gyrocaps, Slo-Phyllin, Theobid, Theo-Dur, Theolair, Theovent, Bronkodyl, Theo-X, Theo-Time, Theochron, Slo-Phyllin 125, Theoclear LA-130, Aerolate JR, Theolair-SR, Theoclear LA-260, Quibron-T, Quibron-T/SR, Uniphyl, Uni-Dur, Aerolate SR, Slo-Phyllin 80, Theoclear-80, Theo-Dur Sprinkles, Theosol-80, Asmalix, Aquaphyllin, Truxophyllin, Slo-Phyllin 250, TheoCap
Synonyms: Theophylline
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Imipenem and Cilastatin Injection-Theophylline Injection
- Imipenem and Cilastatin Injection-Theophylline Intravenous
- Imipenem and Cilastatin Injection-Theophylline Liquid
- Imipenem and Cilastatin Injection-Theophylline Oral Solution
- Imipenem and Cilastatin Injection-Theophylline Sustained-Release Capsules
- Imipenem and Cilastatin Injection-Theophylline Sustained-Release Tablets
- Theophylline in Dextrose-Imipenem and cilastatin Intravenous, Intramuscular
- Theophylline in Dextrose-Imipenem, Cilastatin, and Relebactam
- Theophylline in Dextrose-Imipramine
- Theophylline in Dextrose-Imipramine Capsules
- Theophylline in Dextrose-Imipramine Hydrochloride
- Theophylline in Dextrose-Imipramine Pamoate