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Imipramine Pamoate and Ropivacaine

Determining the interaction of Imipramine Pamoate and Ropivacaine and the possibility of their joint administration.

Check result:

Imipramine Pamoate <> Ropivacaine

Relevance: 25.11.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Imipramine may theoretically increase ropivacaine serum concentrations. The theorized mechanism is via competitive inhibition of CYP450 1A2. The manufacturer recommends caution and close patient monitoring.

References

"Product Information. Naropin (ropivacaine)." Astra USA, Westborough, MA.

Imipramine Pamoate

Generic Name: imipramine

Brand name: Tofranil, Tofranil-PM

Synonyms: Imipramine

What is Imipramine Pamoate?

Ropivacaine

Generic Name: ropivacaine

Brand name: Naropin, Naropin Polyamp, Naropin SDV, Naropin Novaplus

Synonyms: n.a.

What is Ropivacaine?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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