Imodium and Theraflu Nighttime Severe Cold
Determining the interaction of Imodium and Theraflu Nighttime Severe Cold and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using loperamide together with pheniramine may increase side effects such as dizziness, drowsiness, and difficulty concentrating. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Pheniramine may also increase the effects of loperamide on your intestines. Contact your doctor if you experience abdominal cramping or bloating during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with drugs that possess significant anticholinergic activity may potentiate the antimotility effect of loperamide. An isolated case report describes an incident of fatal gastroenteritis during concomitant treatment with clozapine and loperamide. A 36-year-old man who had been treated with clozapine 500 mg/day and was previously in good health died after taking a total of 6 mg of loperamide during an outbreak of intestinal disease in a Finnish hospital. The patient received no other medications. The authors theorized that the anticholinergic effect of clozapine in combination with the antimotility effect of loperamide may have led to toxic megacolon. However, causality has not been determined.
MANAGEMENT: Until further information is available, loperamide should be used with caution in combination with drugs that possess significant anticholinergic activity (e.g., antihistamines; antispasmodics; neuroleptics; phenothiazines; skeletal muscle relaxants; tricyclic antidepressants; class IA antiarrhythmics especially disopyramide). Ambulatory patients should also be made aware of the possibility of additive CNS effects (e.g., drowsiness, dizziness, lightheadedness, confusion) and counseled to avoid activities requiring mental alertness until they know how these agents affect them.
- Eronen M, Putkonen H, Hallikainen T, Vartiainen H "Lethal gastroenteritis associated with clozapine and loperamide." Am J Psychiatry 160 (2003): 2242-2243
Generic Name: loperamide
Brand name: Imodium, Diamode, Imodium A-D, Imodium A-D EZ Chews, Imodium A-D New Formula, Maalox Anti-Diarrheal, Pepto Diarrhea Control, Imotil, Kao-Paverin, Kaopectate 1-D, Diar-Aid, Anti-Diarrheal [OTC]
Synonyms: n.a.
Generic Name: acetaminophen / pheniramine / phenylephrine
Brand name: Flu & Severe Cold Night Time, Theraflu Flu & Sore Throat, Theraflu Nighttime Severe Cold, Theraflu Sinus & Cold, Theraflu Cold & Sore Throat, Theraflu Cold and Sore Throat, Theraflu Flu and Sore Throat
Synonyms: Theraflu Flu & Sore Throat
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Imodium-Theraflu Nighttime Severe Cough and Cold
- Imodium-Theraflu PowerPods (Acetaminophen, Dextromethorphan, and Phenylephrine Pods)
- Imodium-Theraflu PowerPods (Acetaminophen, Diphenhydramine, and Phenylephrine Pods)
- Imodium-Theraflu Severe Cold & Congestion
- Imodium-Theraflu Severe Cold & Congestion Non-Drowsy
- Imodium-Theraflu Severe Cold & Cough Nighttime
- Theraflu Nighttime Severe Cold-Imodium A-D
- Theraflu Nighttime Severe Cold-Imodium A-D EZ Chews
- Theraflu Nighttime Severe Cold-Imodium A-D New Formula
- Theraflu Nighttime Severe Cold-Imodium Multi-Symptom Relief
- Theraflu Nighttime Severe Cold-Imogam Rabies-HT
- Theraflu Nighttime Severe Cold-Imogam Rabies-HT human