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Imogam Rabies-HT human and RabAvert purified chick embryo cell

Determining the interaction of Imogam Rabies-HT human and RabAvert purified chick embryo cell and the possibility of their joint administration.

Check result:
Imogam Rabies-HT human <> RabAvert purified chick embryo cell
Relevance: 18.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Before getting treatment with rabies immune globulin, human and rabies vaccine, purified chick embryo cell, let your doctor know if you have ever been vaccinated for rabies. You generally do not need rabies immune globulin, human if you have received rabies vaccine in the past. If you have never been vaccinated for rabies, you should receive a one-time treatment with rabies immune globulin, human at the time of your first shot of rabies vaccine, or at the latest within seven days of your first shot. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Exceeding the recommended dosage of human rabies immune globulin may reduce the immune response to rabies vaccine. Studies have shown that administration of prophylactic rabies antibody can interfere to a variable extent with the active immunity induced by the vaccine, but that the impact could be minimized by booster doses of vaccine after the end of the usual dosage series. In carefully controlled clinical studies, when a human rabies immune globulin dose of 20 IU/kg of rabies antibody was given simultaneously with the first dose of vaccine, levels of passive rabies antibody were detected 24 hours after injection in all individuals. There was minimal or no interference with the immune response to the initial and subsequent doses of vaccine, including booster doses.

MANAGEMENT: Human rabies immune globulin should be administered at the time of the first dose of rabies vaccine, or up to the eighth day after the first dose of vaccine is given. Under no circumstances should human rabies immune globulin be administered in the same syringe or at the same anatomical site as the vaccine. Because human rabies immune globulin may partially suppress active production of antibody, no more than the recommended dosage of 20 IU/kg should be given. In addition, repeated doses of rabies immune globulin should not be administered once vaccine treatment has been initiated, as this may also interfere with maximum active immunity expected from the vaccine.

References
  • "Product Information. Imogam Rabies-HT (rabies immune globulin, human)." sanofi pasteur, Swiftwater, PA.
  • "Product Information. Bayrab (rabies immune globulin, human)." Bayer, West Haven, CT.
Imogam Rabies-HT human

Generic Name: rabies immune globulin, human

Brand name: Bayrab, HyperRAB, Imogam Rabies-HT, Kedrab

Synonyms: Imogam Rabies-HT (human)

RabAvert purified chick embryo cell

Generic Name: rabies vaccine, purified chick embryo cell

Brand name: RabAvert

Synonyms: RabAvert (purified chick embryo cell), RabAvert

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.