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Impavido and Zovia 1/50e

Determining the interaction of Impavido and Zovia 1/50e and the possibility of their joint administration.

Check result:
Impavido <> Zovia 1/50e
Relevance: 17.04.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Miltefosine may commonly cause diarrhea and/or vomiting, which may affect the absorption of any other oral medication you may take. If you develop diarrhea or vomiting and are taking ethinyl estradiol for birth control, you should use an alternative or additional method of contraception as backup to avoid unintended pregnancy. This is particularly important because miltefosine may cause harm in the unborn child. Talk to your healthcare provider if you have questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADDITIONAL CONTRACEPTION RECOMMENDED: The vomiting and/or diarrhea that commonly occur during miltefosine therapy may affect the absorption of oral contraceptives, potentially compromising their efficacy.

MANAGEMENT: Female patients receiving oral contraceptives should be advised to use additional non-hormonal or alternative method(s) of effective contraception if vomiting or diarrhea occurs during miltefosine therapy. This is particularly important because miltefosine may cause fetal harm. Teratogenicity and fetal death were observed in animals administered miltefosine at dosages lower than the recommended human dosage. Females of reproductive potential should use effective contraception during miltefosine therapy and for 5 months after completion of therapy.

References
  • "Product Information. Impavido (miltefosine)." Paladin Therapeutics Inc, Wilmington, DE.
Impavido

Generic Name: miltefosine

Brand name: Impavido

Synonyms: n.a.

Zovia 1/50e

Generic Name: ethinyl estradiol / ethynodiol

Brand name: Kelnor, Zovia 1/35, Zovia 1/50, Demulen 1/35, Demulen 1/50, Zovia 1/35e, Kelnor 1/50, Kelnor 1/35, Zovia 1/50e

Synonyms: Zovia 1/50, Zovia 1/50E

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle
Disease interaction