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Imuran and Pancuronium

Determining the interaction of Imuran and Pancuronium and the possibility of their joint administration.

Check result:

Imuran <> Pancuronium

Relevance: 24.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Limited data suggest that azathioprine may variously enhance, reduce, or reverse the effects of neuromuscular blockers. The mechanism for enhancement of effects is unknown. The mechanism for reduction of effects may be related to inhibition of phosphodiesterase in motor nerve terminals. The clinical significance is unknown. Routine dose titration and standard monitoring of the patient are recommended.

References

Cerner Multum, Inc. "Australian Product Information." O 0
Gramstad L "Atracurium, vecuronium and pancuronium in end-stage renal failure." Br J Anaesth 59 (1987): 995-1003
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Agencia Española de Medicamentos y Productos Sanitarios Healthcare "Centro de información online de medicamentos de la AEMPS - CIMA. Available from: URL: https://cima.aemps.es/cima/publico/home.html." ([2018]):
Dretchen KL, Norgenroth VH, Standaert FG, Walts LF "Azathioprine: effects on neuromuscular transmission." Anesthesiology 45 (1976): 604-9

Imuran

Generic Name: azathioprine

Brand name: Azasan, Imuran

Synonyms: n.a.

What is Imuran?

Pancuronium

Generic Name: pancuronium

Brand name:

Synonyms: n.a.

What is Pancuronium?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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