Incivek and Intermezzo

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Telaprevir may decrease the blood levels and effects of zolpidem. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with telaprevir may decrease the plasma concentrations of zolpidem. The mechanism of interaction has not been described. In 19 study subjects, administration of a single 5 mg dose of zolpidem during treatment with telaprevir 750 mg every 8 hours for 10 days decreased the zolpidem peak plasma concentration (Cmax) and systemic exposure (AUC) by an average of 42% and 47%, respectively, compared to administration alone.

MANAGEMENT: The possibility of diminished therapeutic effects should be considered when zolpidem is used in combination with telaprevir. Pharmacologic response to zolpidem should be closely monitored and the dosage adjusted if necessary, particularly following the initiation or discontinuation of telaprevir.

Incivek

Generic Name: telaprevir

Brand name: Incivek

Synonyms: n.a.

What is Incivek?

Intermezzo

Generic Name: zolpidem

Brand name: Intermezzo, Ambien, Ambien CR, Edluar, ZolpiMist

Synonyms: n.a.

What is Intermezzo?