Incivek and Kaletra Oral Solution
Determining the interaction of Incivek and Kaletra Oral Solution and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Ritonavir may alter the blood levels and effects of telaprevir, depending on what other HIV medications you are using. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with ritonavir alone (i.e., not as a pharmacokinetic booster of other HIV protease inhibitors) may alter the plasma concentrations of telaprevir, although the acute effects may be different than the chronic effects. In 14 study subjects, administration of a single 750 mg dose of telaprevir in combination with a single 100 mg dose of ritonavir increased the telaprevir peak plasma concentration (Cmax) and systemic exposure (AUC) by an average of 30% and 100%, respectively, compared to administration alone. In contrast, when telaprevir (750 mg every 12 hours) was coadministered with ritonavir (100 mg every 12 hours) for 14 days in five study subjects, the Cmax, AUC and trough plasma concentration (Cmin) of telaprevir decreased by 15%, 24% and 32%, respectively. The reduction in trough concentrations of telaprevir during chronic coadministration of ritonavir may lead to virologic failure.
MANAGEMENT: Increased clinical and laboratory monitoring are warranted when telaprevir is coadministered with ritonavir.
- "Product Information. Incivek (telaprevir)." Vertex Pharmaceuticals, Cambridge, MA.
Generic Name: lopinavir / ritonavir
Brand name: Kaletra
Synonyms: Kaletra
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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