Incivek and Lexapro (Escitalopram Tablets)

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Telaprevir may decrease the blood levels and effects of escitalopram. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with the hepatitis C virus (HCV) NS3/4A protease inhibitors, boceprevir and telaprevir, may decrease the plasma concentrations of escitalopram. The mechanism of interaction has not been described. When a single 10 mg dose of escitalopram was given in combination with boceprevir (800 mg three times a day for 11 days), mean escitalopram peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by approximately 20% each. Likewise, in 13 study subjects, administration of escitalopram (10 mg once daily for 7 days) in combination with telaprevir (750 mg every 8 hours for 14 days) decreased escitalopram Cmax, AUC and trough plasma concentration (Cmin) by an average of 30%, 35% and 42%, respectively, compared to administration alone. Escitalopram had no significant effect on the pharmacokinetics of boceprevir or telaprevir.

MANAGEMENT: The possibility of diminished therapeutic effects should be considered when escitalopram is used in combination with boceprevir or telaprevir. Pharmacologic response to escitalopram should be closely monitored and the dosage adjusted, if necessary, following the initiation or discontinuation of the HCV protease inhibitor.

Incivek

Generic Name: telaprevir

Brand name: Incivek

Synonyms: n.a.

What is Incivek?

Lexapro (Escitalopram Tablets)

Generic Name: escitalopram

Brand name: Lexapro

Synonyms: Lexapro

What is Lexapro (Escitalopram Tablets)?