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Inderal and Maprotiline Hydrochloride

Determining the interaction of Inderal and Maprotiline Hydrochloride and the possibility of their joint administration.

Check result:

Inderal <> Maprotiline Hydrochloride

Relevance: 15.06.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Limited data suggest that propranolol may increase the risk of maprotiline toxicity. The proposed mechanism is decreased hepatic blood flow by propranolol, resulting in reduction of maprotiline metabolism. Patients should be advised to notify their physician if they experience excessive sedation, blurred vision, dry mouth, tremor, or ataxia. The dosage of maprotiline may need to be reduced if an interaction is suspected.

References

Saiz-Ruiz J, Moral L "Delirium induced by association of propranolol." J Clin Psychopharmacol 8 (1988): 77-8
Tollefson G, Lesar T "Effect of propranolol on maprotiline clearance." Am J Psychiatry 141 (1984): 148-9

Inderal

Generic Name: propranolol

Brand name: Inderal LA, Inderal XL, InnoPran XL, Inderal, Hemangeol, InnoPran XL

Synonyms: n.a.

What is Inderal?

Maprotiline Hydrochloride

Generic Name: maprotiline

Brand name: Ludiomil

Synonyms: Maprotiline

What is Maprotiline Hydrochloride?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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