Inderal and Oxcarbazepine Extended-Release Tablets

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

OXcarbazepine may increase the blood levels and effects of propranolol. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you experience increased side effects or your condition changes. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with oxcarbazepine may increase the plasma concentrations of drugs that are substrates of the CYP450 2C19 isoenzyme. The mechanism is decreased clearance due to inhibition of CYP450 2C19 activity by oxcarbazepine and its active metabolite 10-monohydroxy derivative, or MHD. In vivo, the plasma levels of phenytoin, a CYP450 2C19 substrate, increased by up to 40% when oxcarbazepine was given at dosages above 1200 mg/day.

MANAGEMENT: Caution is advised if higher dosages of oxcarbazepine must be used concurrently with medications that undergo metabolism by CYP450 2C19, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever oxcarbazepine is added to or withdrawn from therapy.

Inderal

Generic Name: propranolol

Brand name: Inderal LA, Inderal XL, InnoPran XL, Inderal, Hemangeol, InnoPran XL

Synonyms: n.a.

What is Inderal?

Oxcarbazepine Extended-Release Tablets

Generic Name: oxcarbazepine

Brand name: Oxtellar XR, Trileptal

Synonyms: Oxcarbazepine, OXcarbazepine

What is Oxcarbazepine Extended-Release Tablets?