Inderal and Thiothixene

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Propranolol may inhibit the oxidative metabolism of thioxanthenes. The pharmacologic effects of the thioxanthene may be increased. The mechanism may be related to competitive inhibition of CYP450 2D6-mediated first-pass metabolism. The clinical significance of this interaction is unknown. Atenolol, carteolol, nadolol, and sotalol may be considered as alternatives because they undergo renal elimination and are not expected to interact. If this combination cannot be avoided, decreased dosage of either or both drugs may be necessary and the patient should be closely monitored for cardiovascular or nervous system adverse effects.

Inderal

Generic Name: propranolol

Brand name: Inderal LA, Inderal XL, InnoPran XL, Inderal, Hemangeol, InnoPran XL

Synonyms: n.a.

What is Inderal?

Thiothixene

Generic Name: thiothixene

Brand name: Navane

Synonyms: n.a.

What is Thiothixene?