Inderal LA and Rythmol SR
Determining the interaction of Inderal LA and Rythmol SR and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using propranolol and propafenone together can lower your blood pressure and slow your heart rate. This can cause a slow heartbeat, headaches, arrhythmias, mental status changes, dizziness, or feeling like you might pass out. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment or need your blood pressure checked more often if you take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Propafenone may significantly increase serum levels and effects of some oral beta-blockers. The proposed mechanism is inhibition of CYP450 2D6 first-pass metabolism and decreased hepatic clearance. Data are available for metoprolol and propranolol only; however, other hepatically metabolized oral beta-blockers may also be affected. Renally excreted beta-blockers such as atenolol, carteolol, nadolol, or sotalol are not expected to interact. In addition, negative inotropic effects may be potentiated.
MANAGEMENT: Patients receiving this combination should be monitored for hypotension, heart failure, bradycardia, arrhythmias, and mental status changes. Beta-blocker dosage may be decreased if necessary.
- Hardman JG, Gilman AG, Limbird LE eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 9th ed." New York, NY: McGraw-Hill (1995):
- "Product Information. Cartrol (carteolol)." Abbott Pharmaceutical, Abbott Park, IL.
- Le Coz F, Sauleman P, Poirier JM, Cuche JL, Midavaine M, Rames A, Lecocq B, Jaillon P "Oral pharmacokinetics of bisoprolol in resting and exercising healthy volunteers." J Cardiovasc Pharmacol 18 (1991): 28-34
- "Product Information. Inderal (propranolol)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
- Barbey JT "Clinical pharmacology and beta-blocking efficacy of propafenone." J Cardiovasc Pharmacol 17 (1991): s41-3
- McTavish D, Campoli-Richards D, Sorkin EM "Carvedilol. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy." Drugs 45 (1993): 232-58
- Janku I, Perlik F, Tkaczykova M, Brodanova M "Disposition kinetics and concentration-effect relationship of metipranolol in patients with cirrhosis and healthy subjects." Eur J Clin Pharmacol 42 (1992): 337-40
- Piquette-Miller M, Foster RT, Kappagoda CT, Jamali F "Effect of aging on the pharmacokinetics of acebutolol enantiomers." J Clin Pharmacol 32 (1992): 148-56
- Wagner F, Kalusche D, Trenk D, et al "Drug interaction between propafenone and metoprolol." Br J Clin Pharmacol 24 (1987): 213-20
- "Product Information. Blocadren (timolol)." Merck & Co, Inc, West Point, PA.
- "Product Information. Levatol (penbutolol)." Reed and Carnrick, Jersey City, NJ.
- "Product Information. Normodyne (labetalol)." Schering Laboratories, Kenilworth, NJ.
- Ahmad S "Metoprolol-induced delirium perpetuated by propafenone." Am Fam Physician 44 (1991): 1142,4
- Morgan T "Clinical pharmacokinetics and pharmacodynamics of carvedilol." Clin Pharmacokinet 26 (1994): 335-46
- McGourty JC, Silas JH, Fleming JJ, McBurney A, Ward JW "Pharmacokinetics and beta-blocking effects of timolol in poor and extensive metabolizers of debrisoquin." Clin Pharmacol Ther 38 (1985): 409-13
- Wagner F, Kalusche D, Trenk D, Jahnchen E, Roskamm H "Drug interaction between propafenone and metoprolol." Br J Clin Pharmacol 24 (1987): 213-20
- "Product Information. Rhythmol (propafenone)." Knoll Pharmaceutical Company, Whippany, NJ.
- Stagni G, Davis PJ, Ludden TM "Human pharmacokinetics of betaxolol enantiomers." J Pharm Sci 80 (1991): 321-4
- "Product Information. Betapace (sotalol)." Berlex, Richmond, CA.
- "Product Information. Brevibloc (esmolol)." DuPont Pharmaceuticals, Wilmington, DE.
- Amemiya M, Tabei K, Furuya H, Sakairi Y, Asano Y "Pharmacokinetics of carteolol in patients with impaired renal function." Eur J Clin Pharmacol 43 (1992): 417-21
- "Product Information. Corgard (nadolol)." Bristol-Myers Squibb, Princeton, NJ.
- Kowey PR, Kirsten EB, Fu CJ, Mason WD "Interaction between propranolol and propafenone in healthy volunteers." J Clin Pharmacol 29 (1989): 512-7
- "Product Information. Tenormin (atenolol)." ICN Pharmaceuticals Inc, Cost Mesa, CA.
- Seffart G ed. "Drug Dosage in Renal Insufficiency." Dordrecht, South Holland, : Kluwer Academic Publishers (1991):
- Smith RL "Polymorphic metabolism of the beta-adrenoreceptor blocking drugs and its clinical relevance." Eur J Clin Pharmacol 28 (1985): 77-84
Generic Name: propranolol
Brand name: Hemangeol, Inderal LA, Inderal XL, InnoPran XL, Inderal, InnoPran XL
Synonyms: n.a.
Generic Name: propafenone
Brand name: Rythmol, Rythmol SR
Synonyms: Rythmol Extended Release
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.