Inderal XL and Valium injection
Determining the interaction of Inderal XL and Valium injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:The pharmacologic effects of some benzodiazepines may be increased by some beta-blockers. Propranolol and metoprolol may inhibit the hepatic metabolism of diazepam and other mechanisms may also be involved. Most changes have been clinically insignificant; however, increased reaction times and/or decreased kinetic visual acuity have been reported with some combinations. Observation for altered benzodiazepine effects is recommended if these drugs must be used together. Patients should be warned against driving or operating hazardous machinery.
- Ochs HR, Greenblatt DJ, Locniskar A, Weinbrenner J "Influence of propranolol coadministration or cigarette smoking on the kinetics of desmethyldiazepam following intravenous clorazepate." Klin Wochenschr 64 (1986): 1217-21
- Sonne J, Dossing M, Loft S, et al "Single dose pharmacokinetics and pharmacodynamics of oral oxazepam during concomitant administration of propranolol and labetalol." Br J Clin Pharmacol 29 (1990): 33-7
- Hawksworth G, Betts T, Crowe A, et al "Diazepam/beta-adrenoceptor antagonist interactions." Br J Clin Pharmacol 17 Suppl 1 (1984): s69-76
- Klotz U, Reimann IW "Pharmacokinetic and pharmacodynamic interaction study of diazepam and metoprolol." Eur J Clin Pharmacol 26 (1984): 223-6
- Ochs HR, Greenblatt DJ, Verburg-Ochs B "Propranolol interactions with diazepam, lorazepam and alprazolam." Clin Pharmacol Ther 36 (1984): 451-5
- Scott AK, Cameron GA, Hawksworth GM "Interaction of metoprolol with lorazepam and bromazepam." Eur J Clin Pharmacol 40 (1991): 405-9
Generic Name: propranolol
Brand name: Hemangeol, Inderal LA, Inderal XL, InnoPran XL, Inderal, InnoPran XL
Synonyms: n.a.
Generic Name: diazepam
Brand name: Valium, Diastat, Diastat AcuDial, Diastat Pediatric, Diazepam Intensol, Zetran
Synonyms: Valium
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Inderal XL-Valproate
- Inderal XL-Valproate Injection
- Inderal XL-Valproate sodium Intravenous
- Inderal XL-Valproic acid
- Inderal XL-Valproic Acid and Derivatives
- Inderal XL-Valproic Acid Capsules
- Valium injection-Inderide
- Valium injection-Indiclor
- Valium injection-Indinavir
- Valium injection-Indinavir Sulfate
- Valium injection-Indiomin MB
- Valium injection-Indium 111 Oxyquinoline