Indinavir and Khedezla

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using desvenlafaxine together with indinavir may decrease the effects of indinavir. Contact your doctor if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with venlafaxine may decrease the plasma concentrations of indinavir. The mechanism of interaction has not been described. In nine healthy volunteers, administration of indinavir (800 mg single oral dose) in combination with venlafaxine (50 mg every 8 hours for 10 days) resulted in a 36% decrease in indinavir peak plasma concentration (Cmax) and a 28% decrease in systemic exposure compared to administration of indinavir alone. The clinical significance of these alterations is unknown. Indinavir had negligible effects on the pharmacokinetics of venlafaxine. Although not studied, the interaction may also be expected with desvenlafaxine, the prodrug of venlafaxine.

MANAGEMENT: Given the risk of reduced viral susceptibility and resistance development associated with subtherapeutic antiretroviral drug levels, caution is advised if indinavir is used with venlafaxine or desvenlafaxine until further information is available. Patients stabilized on their antiretroviral regimen should be monitored for potentially diminished clinical response during concomitant therapy with venlafaxine.

Indinavir

Generic Name: indinavir

Brand name: Crixivan

Synonyms: n.a.

What is Indinavir?

Khedezla

Generic Name: desvenlafaxine

Brand name: Khedezla, Pristiq

Synonyms: n.a.

What is Khedezla?