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Indinavir Sulfate and Isoniazid Oral Solution

Determining the interaction of Indinavir Sulfate and Isoniazid Oral Solution and the possibility of their joint administration.

Check result:

Indinavir Sulfate <> Isoniazid Oral Solution

Relevance: 21.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Indinavir has been shown to increase the plasma concentration of isoniazid. The mechanism probably is competitive inhibition of isoniazid metabolism. The mean increase in the area under the plasma concentration-time curve of isoniazid was 13%. This interaction is unlikely to be of clinical importance, although it may be appropriate to monitor the patient for isoniazid-related toxicities.

References

"Product Information. Crixivan (indinavir)." Merck & Co, Inc, West Point, PA.

Indinavir Sulfate

Generic Name: indinavir

Brand name: Crixivan

Synonyms: Indinavir

What is Indinavir Sulfate?

Isoniazid Oral Solution

Generic Name: isoniazid

Brand name: Nydrazid

Synonyms: Isoniazid

What is Isoniazid Oral Solution?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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