Indinavir Sulfate and Ivabradine
Determining the interaction of Indinavir Sulfate and Ivabradine and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using ivabradine together with indinavir is not recommended. Combining these medications may significantly increase the blood levels and effects of ivabradine, which may result in excessive slowing of heart rate or other conduction disturbances. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:CONTRAINDICATED: Coadministration with potent inhibitors of CYP450 3A4 may significantly increase the plasma concentrations of ivabradine, which is primarily metabolized by the isoenzyme. According to the product labeling, administration of ivabradine with the potent CYP450 3A4 inhibitor ketoconazole (200 mg once daily) resulted in approximately 3.5- and 7-fold increases in ivabradine peak plasma concentration (Cmax) and systemic exposure (AUC), respectively, compared to administration of ivabradine alone. Elevated plasma levels of ivabradine may increase the risk of excessive bradycardia and conduction disturbances.
MANAGEMENT: Concomitant use of ivabradine with potent CYP450 3A4 inhibitors is considered contraindicated.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- "Product Information. Corlanor (ivabradine)." Amgen USA, Thousand Oaks, CA.
Generic Name: indinavir
Brand name: Crixivan
Synonyms: Indinavir
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Indinavir Sulfate-Ivabradine Hydrochloride
- Indinavir Sulfate-Ivabradine Oral Solution
- Indinavir Sulfate-Ivabradine Tablets
- Indinavir Sulfate-Ivacaftor
- Indinavir Sulfate-Ivacaftor and lumacaftor
- Indinavir Sulfate-Ivacaftor and tezacaftor
- Ivabradine-Indiomin MB
- Ivabradine-Indium 111 Oxyquinoline
- Ivabradine-Indium DTPA
- Ivabradine-Indium In-111 Pentetreotide
- Ivabradine-Indium Oxyquinoline
- Ivabradine-Indocid