Indinavir Sulfate and Methadone Injection Solution
Determining the interaction of Indinavir Sulfate and Methadone Injection Solution and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Indinavir does not appear to significantly affect the pharmacokinetics of methadone. In 12 study subjects on methadone maintenance treatment, coadministration of methadone (20 to 60 mg once daily) and indinavir (800 mg three times daily) for 8 days resulted in no changes to methadone peak plasma concentration, systemic exposure (AUC), or trough plasma concentration. Methadone also had negligible effects on indinavir pharmacokinetics, as indinavir AUC in the study were similar to historical data. Based on these findings, no dosage adjustments are necessary for either methadone or indinavir during coadministration.
- "Product Information. Dolophine (methadone)." Lilly, Eli and Company, Indianapolis, IN.
Generic Name: indinavir
Brand name: Crixivan
Synonyms: Indinavir
Generic Name: methadone
Brand name: Dolophine, Methadose, Methadose Sugar-Free, Diskets
Synonyms: Methadone
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Indinavir Sulfate-Methadone Oral Concentrate
- Indinavir Sulfate-Methadone Oral Solution
- Indinavir Sulfate-Methadone Powder
- Indinavir Sulfate-Methadone Solution
- Indinavir Sulfate-Methadone Tablets
- Indinavir Sulfate-Methadone Tablets for Oral Suspension
- Methadone Injection Solution-Indiomin MB
- Methadone Injection Solution-Indium 111 Oxyquinoline
- Methadone Injection Solution-Indium DTPA
- Methadone Injection Solution-Indium In-111 Pentetreotide
- Methadone Injection Solution-Indium Oxyquinoline
- Methadone Injection Solution-Indocid