Indinavir Sulfate and Quinidex Extentabs

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using quiNIDine together with indinavir can increase the effects of quiNIDine and affect the rhythm of your heart. Call your doctor if you have symptoms of irregular heartbeat, chest tightness, blurred vision or nausea. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with indinavir may significantly increase the plasma concentrations of some antiarrhythmic agents such as bepridil, quinidine, and lidocaine. The proposed mechanism is indinavir inhibition of CYP450 3A4, the isoenzyme responsible for the metabolic clearance of these agents. Although clinical data are lacking, the interaction could conceivably lead to serious and/or life-threatening reactions including QT interval prolongation and ventricular arrhythmias such as ventricular tachycardia and torsade de pointes.

MANAGEMENT: Caution is advised if indinavir must be used with antiarrhythmic agents. Pharmacologic response should be monitored more closely whenever indinavir is added to or withdrawn from therapy, and the dosage adjusted as necessary.

Indinavir Sulfate

Generic Name: indinavir

Brand name: Crixivan

Synonyms: Indinavir

What is Indinavir Sulfate?

Quinidex Extentabs

Generic Name: quinidine

Brand name: Quin-G, Cardioquin, Quinora, Quinidex Extentabs, Quinaglute Dura-Tabs, Quin-Release

Synonyms: n.a.

What is Quinidex Extentabs?