Drug search by name

Indinavir Sulfate and Sporanox PulsePak

Determining the interaction of Indinavir Sulfate and Sporanox PulsePak and the possibility of their joint administration.

Check result:

Indinavir Sulfate <> Sporanox PulsePak

Relevance: 21.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using indinavir together with itraconazole can increase the effects of indinavir. Contact your doctor if you experience more side effects or if your condition changes. If your doctor prescribes these medications together, you may need a dose adjustment or special tests to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSE: Coadministration with itraconazole may significantly increase the plasma concentrations of indinavir. The mechanism is decreased clearance due to inhibition of CYP450 3A4 activity by itraconazole.

MANAGEMENT: The manufacturer recommends that the indinavir dose be reduced to 600 mg every 8 hours during concurrent administration. The patient should be monitored for the therapeutic and adverse effects of indinavir, and dosage adjustments should be made as necessary.

References

"Product Information. Crixivan (indinavir)." Merck & Co, Inc, West Point, PA.

Indinavir Sulfate

Generic Name: indinavir

Brand name: Crixivan

Synonyms: Indinavir

What is Indinavir Sulfate?

Sporanox PulsePak

Generic Name: itraconazole

Brand name: Sporanox, Onmel, Sporanox PulsePak, Tolsura

Synonyms: Sporanox

What is Sporanox PulsePak?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions