Indinavir Sulfate and Synalgos-DC Oral

• Generic Name: indinavir
• Dosage Forms: n.a.
• Other Brand Names: Crixivan

Treatment of HIV infection in adults, adolescents, and pediatric patients; used in conjunction with other antiretrovirals.

Experts state indinavir not recommended for initial treatment regimens in antiretroviral-naive adults and adolescents because of inconvenient dosing regimen, fluid requirements, and toxicities (e.g., nephrolithiasis, crystalluria).

Indinavir with low-dose ritonavir (ritonavir-boosted indinavir) not recommended for initial therapy in antiretroviral-naive adults and adolescents because of fluid requirements and toxicities (e.g., nephrolithiasis, crystalluria).

Indinavir (with or without low-dose ritonavir) not recommended for initial treatment regimens in antiretroviral-naive pediatric patients because of high incidence of hematuria, sterile leukocyturia, and nephrolithiasis in children.

• Generic Name: aspirin / caffeine / dihydrocodeine
• Dosage Forms: capsule
• Other Brand Names: Synalgos-DC

Aspirin, caffeine, and dihydrocodeine combination is used to relieve pain severe enough to require opioid treatment and when other pain medicines did not work well enough or cannot be tolerated.

Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) that is used to relieve pain and reduce fever in patients. Caffeine is a CNS stimulant that is used together with pain relievers to increase their effect. It has also been used for migraine headaches. Dihydrocodeine belongs to the group of medicines called narcotic analgesics (pain medicines). It acts on the central nervous system (CNS) to relieve pain.

When dihydrocodeine is used for a long time or in large doses, it may become habit-forming, causing mental or physical dependence. However, people who have continuing pain should not let the fear of dependence keep them from using narcotics to relieve their pain. Mental dependence (addiction) is not likely to occur when narcotics are used for this purpose. Physical dependence may lead to withdrawal side effects if treatment is stopped suddenly. However, severe withdrawal side effects can usually be prevented by gradually reducing the dose over a period of time before treatment is stopped completely.

This medicine is available only under a restricted distribution program called the Opioid Analgesic REMS (Risk Evaluation and Mitigation Strategy) program.