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Indinavir Sulfate and Xanax

Determining the interaction of Indinavir Sulfate and Xanax and the possibility of their joint administration.

Check result:

Indinavir Sulfate <> Xanax

Relevance: 21.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using ALPRAZolam and indinavir is not recommended. Taking these drugs together can cause symptoms of slurred speech, confusion, severe weakness, or difficulty breathing. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

CONTRAINDICATED: Coadministration with indinavir may significantly increase the plasma concentrations and pharmacologic effects of alprazolam. The proposed mechanism is indinavir inhibition of intestinal and hepatic CYP450 3A4, the isoenzyme responsible for the first-pass and hepatic metabolism of alprazolam.

MANAGEMENT: Given the potential for prolonged and/or increased sedation and respiratory depression associated with excessive benzodiazepine blood levels, concomitant use of indinavir with alprazolam is considered contraindicated.

References

"Product Information. Crixivan (indinavir)." Merck & Co, Inc, West Point, PA.

Indinavir Sulfate

Generic Name: indinavir

Brand name: Crixivan

Synonyms: Indinavir

What is Indinavir Sulfate?

Xanax

Generic Name: alprazolam

Brand name: Niravam, Xanax, Xanax XR, Alprazolam Intensol

Synonyms: n.a.

What is Xanax?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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