Indinavir Sulfate and Xylocaine HCl
Determining the interaction of Indinavir Sulfate and Xylocaine HCl and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using lidocaine together with indinavir can increase the effects of lidocaine and affect the rhythm of your heart. Call your doctor if you have symptoms of irregular heartbeat, chest tightness, blurred vision or nausea. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with indinavir may significantly increase the plasma concentrations of some antiarrhythmic agents such as bepridil, quinidine, and lidocaine. The proposed mechanism is indinavir inhibition of CYP450 3A4, the isoenzyme responsible for the metabolic clearance of these agents. Although clinical data are lacking, the interaction could conceivably lead to serious and/or life-threatening reactions including QT interval prolongation and ventricular arrhythmias such as ventricular tachycardia and torsade de pointes.
MANAGEMENT: Caution is advised if indinavir must be used with antiarrhythmic agents. Pharmacologic response should be monitored more closely whenever indinavir is added to or withdrawn from therapy, and the dosage adjusted as necessary.
- "Product Information. Crixivan (indinavir)." Merck & Co, Inc, West Point, PA.
Generic Name: indinavir
Brand name: Crixivan
Synonyms: Indinavir
Generic Name: lidocaine
Brand name: UAD Caine, Xylocaine HCl, Xylocaine-MPF, Lidoject 1, Xylocaine Dental Cartridges, Lidoject 2, Xylocaine Duo-Trach Kit, Xylocaine HCl For Spinal, L-Caine, Dilocaine, Nervocaine, Truxacaine, Anestacaine
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Indinavir Sulfate-Xylocaine Jelly
- Indinavir Sulfate-Xylocaine MPF
- Indinavir Sulfate-Xylocaine MPF With Epinephrine
- Indinavir Sulfate-Xylocaine Topical application
- Indinavir Sulfate-Xylocaine Topical Solution
- Indinavir Sulfate-Xylocaine With Epinephrine
- Xylocaine HCl-Indiomin MB
- Xylocaine HCl-Indium 111 Oxyquinoline
- Xylocaine HCl-Indium DTPA
- Xylocaine HCl-Indium In-111 Pentetreotide
- Xylocaine HCl-Indium Oxyquinoline
- Xylocaine HCl-Indocid