Indiomin MB and Zolmitriptan Orally Disintegrating Tablets

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using ZOLMitriptan together with methylene blue is not recommended. Combining these medications may significantly increase the blood levels and effects of ZOLMitriptan, which in some cases can lead to excessive narrowing of blood vessels in the body. This can reduce blood flow to vital organs and increase the risk of rare but serious side effects such as high blood pressure, heart attack, stroke, and gangrene (death of tissues, usually in the arm or leg, that may require surgical amputation). Additionally, using ZOLMitriptan and methylene blue together can increase the risk of a rare but serious condition called the serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. Severe cases may result in coma and even death. In general, you should wait at least 14 days after stopping methylene blue before you start treatment with ZOLMitriptan. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

CONTRAINDICATED: Monoamine oxidase inhibitors (MAOIs) may significantly elevate the plasma concentrations of certain 5-HT1 receptor agonists (namely rizatriptan, sumatriptan, and zolmitriptan) and their active metabolites by inhibiting their metabolic clearance via monoamine oxidase, subtype A. Clinically, this interaction may increase the risk of vasospastic reactions, including coronary artery vasospasm, peripheral vascular ischemia and colonic ischemia, associated with the use of 5-HT1 receptor agonists. Although the pharmacokinetic alterations are observed only with a limited number of 5-HT1 receptor agonists and their metabolites, the possibility of a pharmacodynamic interaction should be considered for all agents in the class, since they exhibit modest 5-HT1A activity. Theoretically, MAOIs may potentiate the serotonergic activity of these agents and increase the risk of serotonin syndrome, which is a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5-HT1A and 2A receptors. The mechanism is inhibition of the breakdown of serotonin by MAOIs. Symptoms of the serotonin syndrome may include mental status changes such as irritability, altered consciousness, confusion, hallucinations, and coma; autonomic dysfunction such as tachycardia, hyperthermia, diaphoresis, shivering, blood pressure lability, and mydriasis; neuromuscular abnormalities such as hyperreflexia, myoclonus, tremor, rigidity, and ataxia; and gastrointestinal symptoms such as abdominal cramping, nausea, vomiting, and diarrhea.

MANAGEMENT: Concomitant use of rizatriptan, sumatriptan, or zolmitriptan with MAOIs or other agents that possess MAOI activity (e.g., furazolidone, linezolid, methylene blue, procarbazine) is considered contraindicated. At least 14 days should elapse between discontinuation of MAOI therapy and initiation of treatment with 5-HT1 receptor agonists. If concurrent therapy is necessary, almotriptan, frovatriptan and naratriptan may be preferred due to the lack of a significant pharmacokinetic interaction with MAOIs. However, patients should be closely monitored for adverse effects related to excessive serotonergic activity.

Indiomin MB

Generic Name: hyoscyamine / methenamine / methylene blue / sodium biphosphate

Brand name: Indiomin MB, ME/NaPhos/MB/Hyo1, Uro-BLUE, Urogesic-Blue, Urolet MB, UTA, UTA

Synonyms: n.a.

What is Indiomin MB?

Zolmitriptan Orally Disintegrating Tablets

Generic Name: zolmitriptan

Brand name: Zomig, Zomig-ZMT

Synonyms: Zolmitriptan, ZOLMitriptan

What is Zolmitriptan Orally Disintegrating Tablets?