Indomethacin ER and Propranolol Oral Solution (Hemangeol)
Determining the interaction of Indomethacin ER and Propranolol Oral Solution (Hemangeol) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:If you use propranolol for the treatment of high blood pressure, talk to your doctor before using it together with indomethacin. Combining these medications may reduce the effects of propranolol in lowering your blood pressure, especially if you use indomethacin frequently or regularly (for example, to treat arthritis or chronic pain). You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Nonsteroidal anti-inflammatory drugs (NSAIDs) may attenuate the antihypertensive effect of beta-blockers. The proposed mechanism is NSAID-induced inhibition of renal prostaglandin synthesis, which results in unopposed pressor activity producing hypertension. In addition, NSAIDs can cause fluid retention, which also affects blood pressure. Indomethacin and piroxicam have been reported to have greater attenuating effects than other NSAIDs, and indomethacin effects may be significant in patients with eclampsia.
MANAGEMENT: Patients receiving a beta-blocker who require prolonged (greater than 1 week) concomitant therapy with an NSAID should have blood pressure monitored more closely following initiation, discontinuation, or change of dosage of the NSAID. The interaction is not expected to occur with low doses (e.g., low-dose aspirin) or intermittent short-term administration of NSAIDs.
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Generic Name: indomethacin
Brand name: Indocin, Indocin SR, Tivorbex
Synonyms: Indomethacin
Generic Name: propranolol
Brand name: Hemangeol, Inderal LA, Inderal XL, InnoPran XL, Inderal, InnoPran XL
Synonyms: Propranolol
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Indomethacin ER-Propranolol Sustained-Release Bead Capsules
- Indomethacin ER-Propranolol Sustained-Release Capsules
- Indomethacin ER-Propranolol Tablets
- Indomethacin ER-Proprinal
- Indomethacin ER-Propulsid
- Indomethacin ER-Propulsid (Cisapride Suspension)
- Propranolol Oral Solution (Hemangeol)-Indomethacin Extended-Release Capsules
- Propranolol Oral Solution (Hemangeol)-Indomethacin Injection
- Propranolol Oral Solution (Hemangeol)-Indomethacin Intravenous
- Propranolol Oral Solution (Hemangeol)-Indomethacin Rectal
- Propranolol Oral Solution (Hemangeol)-Indomethacin Suppositories
- Propranolol Oral Solution (Hemangeol)-Indomethacin Suppository