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Influenza Virus Vaccine (Recombinant) and Jantoven

Determining the interaction of Influenza Virus Vaccine (Recombinant) and Jantoven and the possibility of their joint administration.

Check result:
Influenza Virus Vaccine (Recombinant) <> Jantoven
Relevance: 04.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using warfarin together with influenza virus vaccine, inactivated may cause you to bleed more easily. You may need a dose adjustment based on your prothrombin time or International Normalized Ratio (INR). Call your doctor promptly if you have any unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Rare case reports have suggested that the administration of influenza vaccine to patients taking warfarin may result in increased INR and/or bleeding. The mechanism is unknown and causality was not clearly established. Subsequent studies have reported that influenza vaccine did not affect coagulation parameters or warfarin metabolism.

MANAGEMENT: It may be advisable to monitor anticoagulated patients for several days after administering influenza vaccine.

References
  • "Product Information. Coumadin (warfarin)." DuPont Pharmaceuticals, Wilmington, DE.
Influenza Virus Vaccine (Recombinant)

Generic Name: influenza virus vaccine, inactivated

Brand name: Afluria, Agriflu, Fluad 2019-2020, Fluarix, Flublok Quadrivalent 2019-2020, Flucelvax, FluLaval, Fluogen, Flushield, Fluvirin, Fluzone, Flucelvax, Fluzone Intradermal Quadrivalent, Fluzone Quadrivalent, Flublok, Flublok Quadrivalent

Synonyms: Influenza virus vaccine (injection), Influenza Virus Vaccine (Inactivated)

Jantoven

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle