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Infumorph and Propulsid (Cisapride Tablets)

Determining the interaction of Infumorph and Propulsid (Cisapride Tablets) and the possibility of their joint administration.

Check result:

Infumorph <> Propulsid (Cisapride Tablets)

Relevance: 17.05.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Cisapride may increase plasma concentrations of morphine, possibly because of its gastrokinetic effects. However, this interaction was not associated with an increase in sedation in 20 patients given 20 mg of sustained-release morphine and 20 mg of cisapride. The clinical significance for patients receiving larger doses of morphine is unknown.

References

Rowbotham DJ, Milligan K, McHugh P "Effect of cisapride on morphine absorption after oral administration of sustained-release morphine." Br J Anaesth 67 (1991): 421-5
Greiff JMC, Rowbotham D "Pharmacokinetic drug interactions with gastrointestinal motility modifying agents." Clin Pharmacokinet 27 (1994): 447-61

Infumorph

Generic Name: morphine

Brand name: Duramorph PF, Infumorph, Mitigo, Arymo ER, Kadian, MorphaBond ER, Avinza, MS Contin, RMS, Roxanol

Synonyms: Infumorph (injection)

What is Infumorph?

Propulsid (Cisapride Tablets)

Generic Name: cisapride

Brand name: Propulsid

Synonyms: Propulsid (Suspension), Propulsid

What is Propulsid (Cisapride Tablets)?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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