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Infumorph and Trovan

Determining the interaction of Infumorph and Trovan and the possibility of their joint administration.

Check result:

Infumorph <> Trovan

Relevance: 17.05.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Trovafloxacin is no longer on the market in the US. Do not take trovafloxacin with any other medication.

Professional:

ADJUST DOSING INTERVAL: Coadministration of oral trovafloxacin with intravenous morphine significantly decreases the absorption of trovafloxacin. Loss of efficacy may result. The mechanism of the interaction is not known.

MANAGEMENT: If these drugs must be coadministered, intravenous morphine should be administered at least two hours after the oral trovafloxacin dose in the fasted state and at least four hours after oral trovafloxacin in the fed state.

References

"Product Information. Trovan (trovafloxacin)." Pfizer US Pharmaceuticals, New York, NY.
Vincent J, Hunt T, Teng RL, Robarge L, Willavize SA, Friedman HL "The pharmacokinetic effects of coadministration of morphine and trovafloxacin in healthy subjects." Am J Surg 176 (1998): s32-8

Infumorph

Generic Name: morphine

Brand name: Duramorph PF, Infumorph, Mitigo, Arymo ER, Kadian, MorphaBond ER, Avinza, MS Contin, RMS, Roxanol

Synonyms: Infumorph (injection)

What is Infumorph?

Trovan

Generic Name: trovafloxacin

Brand name:

Synonyms: n.a.

What is Trovan?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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