InnoPran XL and Intuniv

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using propranolol and guanFACINE together may have additive effects in lowering your blood pressure and altering your heart rate. You may experience changes in pulse or heart rate, headaches, dizziness, or feeling like you might pass out. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment or need your blood pressure checked more often to safely use both medications. Avoid driving or operating hazardous machinery until you know how the medications affect you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Use of central alpha-2 adrenergic agonists, such as clonidine or guanfacine, with beta-blockers may have synergistic pharmacodynamic effects resulting in AV block, bradycardia, and hypotension. In addition, sinus node dysfunction may also be enhanced. Abrupt withdrawal of an alpha-2 agonist or both the alpha-2 agonist and the beta-blocker may also result in rebound hypertensive effects. Increased blood pressure, hypertensive crisis, hypertensive encephalopathy, strokes, and fatalities have been reported after clonidine withdrawal. The proposed mechanism is related to increased catecholamine release after alpha-2 agonist withdrawal which, when combined with concurrent beta-blockade, results in unopposed vasoconstriction. Data are available for clonidine; however, the manufacturer of guanfacine states that beta-blockers and guanfacine have been given concomitantly without evidence of any interactions in long-term safety studies. Patients who discontinued clonidine while taking noncardioselective beta blockers appeared to be at a higher risk of developing rebound hypertension.

MANAGEMENT: Until more information is available, caution and close monitoring of blood pressure are recommended for patients receiving guanfacine with a beta-blocker. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some patients. Patients should be advised to avoid rising abruptly from a sitting or recumbent position and to notify their physician if they experience dizziness, lightheadedness, syncope, headaches, or reduced or irregular heart rate.

InnoPran XL

Generic Name: propranolol

Brand name: Hemangeol, Inderal LA, Inderal XL, InnoPran XL, Inderal, InnoPran XL

Synonyms: n.a.

What is InnoPran XL?

Intuniv

Generic Name: guanfacine

Brand name: Intuniv, Tenex

Synonyms: n.a.

What is Intuniv?