Drug search by name

InnoPran XL and Lanoxin Tablets

Determining the interaction of InnoPran XL and Lanoxin Tablets and the possibility of their joint administration.

Check result:

InnoPran XL <> Lanoxin Tablets

Relevance: 11.01.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using propranolol together with digoxin may slow your heart rate and lead to increased side effects. Contact your doctor if you experience nausea, vomiting, decreased appetite, diarrhea, confusion, seizures, visual changes, fatigue, irregular heartbeats, and abnormally fast or slow heartbeats. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Concomitant use of digitalis glycosides and beta-blockers may increase the risk of bradycardia. These agents slow atrioventricular conduction and decrease heart rate, hence they may have additive cardiac effects during coadministration. Some beta-blockers such as carvedilol, esmolol, and talinolol have also been reported to increase the systemic bioavailability of digoxin. The mechanism may involve enhanced absorption as well as reduced renal excretion of digoxin due to inhibition of intestinal and renal P-glycoprotein efflux transporter.

MANAGEMENT: Caution is advised during coadministration of digitalis glycosides and beta-blockers. Serum digitalis levels, heart rate, and blood pressure should be monitored closely, particularly during the first few weeks of concomitant therapy. Patients should be advised to notify their physician if they experience anorexia, nausea, visual changes, irregular heartbeat, slow pulse, dizziness, or syncope. Beta-blockers should not be used in patients with overt or decompensated congestive heart failure, as sympathetic stimulation may be a vital component in maintaining hemodynamic function in these patients and its inhibition by beta blockade may worsen the heart failure.

References

Lowenthal DT, Porter RS, Saris SD, Bies CM, Slegowski MB, Staudacher A "Clinical pharmacology, pharmacodynamics and interactions with esmolol." Am J Cardiol 56 (1985): f14-8
De Mey C, Brendel E, Enterling D "Carvedilol increases the systemic bioavailability of oral digoxin." Br J Clin Pharmacol 29 (1990): 486-90
Takara K, Kakumoto M, Tanigawara Y, Funakoshi J, Sakaeda T, Okumura K "Interaction of digoxin with antihypertensive drugs via MDR 1." Life Sci 70 (2002): 1491-1500
"Product Information. Zebeta (bisoprolol)." Lederle Laboratories, Wayne, NJ.
Watt DA "Sensitivity to propranolol after digoxin intoxication." Br Med J 2 (1968): 413-4
LeWinter MM, Crawford MH, O'Rourke RA, Karliner JS "The effects of oral propranolol, digoxin and combination therapy on the resting and exercise electrocardiogram." Am Heart J 93 (1977): 202-9
Ratnapalan S, Griffiths K, Costei AM, Benson L, Koren G "Digoxin-carvedilol interactions in children." J Pediatr 142 (2003): 572-574
"Product Information. Inderal (propranolol)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
"Product Information. Coreg (carvedilol)." SmithKline Beecham, Philadelphia, PA.
Wermeling DP, Field CJ, Smith DA, Chandler MH, Clifton GD, Boyle DA "Effects of long-term oral carvedilol on the steady-state pharmacokinetics of oral digoxin in patients with mild to moderate hypertension." Pharmacotherapy 14 (1994): 600-6
Eichhorn EJ, Lukas MA, Wu B, Shusterman N "Effect of concomitant digoxin and carvedilol therapy of mortality and morbidity in patients with chronic heart failure." Am J Cardiol 86 (2000): 1032-5
Lowenthal DT, Porter RS, Achari R, Turlapaty P, Laddu AR, Matier WL "Esmolol-digoxin drug interaction" J Clin Pharmacol 27 (1987): 561-6

InnoPran XL

Generic Name: propranolol

Brand name: Hemangeol, Inderal LA, Inderal XL, InnoPran XL, Inderal, InnoPran XL

Synonyms: n.a.

What is InnoPran XL?

Lanoxin Tablets

Generic Name: digoxin

Brand name: Digitek, Digox, Lanoxin, Lanoxicaps, Cardoxin

Synonyms: Digoxin

What is Lanoxin Tablets?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions