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InnoPran XL and Lidocaine injection

Determining the interaction of InnoPran XL and Lidocaine injection and the possibility of their joint administration.

Check result:

InnoPran XL <> Lidocaine injection

Relevance: 11.01.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using lidocaine together with propranolol may increase the effects of lidocaine. This can cause drowsiness, mental status changes, and a decrease in heart rate and blood pressure. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Some beta-blockers may increase lidocaine levels and risk of toxicity. The proposed mechanism is enzyme inhibition and/or decreased cardiac output and hepatic blood flow resulting in decreased hepatic metabolism of lidocaine. In addition beta-blockers and lidocaine may also have additive negative inotropic effects on the heart. Data have been conflicting and variable.

MANAGEMENT: Patients receiving concurrent therapy should be monitored for drowsiness, mental status changes, bradycardia, and hypotension. Lidocaine levels should be obtained when clinically necessary. If toxicity is suspected, the lidocaine infusion should be decreased, as possible.

References

Ochs HR, Carstens G, Greenblatt DJ "Reduction in lidocaine clearance during continuous infusion and by coadministration of propranolol." N Engl J Med 303 (1980): 373-7
Svendsen TL, Tango M, Waldorff S, et al "Effects of propranolol and pindolol on plasma lignocaine clearance in man." Br J Clin Pharmacol 13 (1982): s223-6
Graham CF, Turner WM, Jones JK "Lidocaine-propranolol interactions ." N Engl J Med 304 (1981): 1301
Miners JO, Wing MH, Lillywhite KJ, Smith KJ "Failure of "therapeutic" doses of beta-adrenoceptor antagonists to alter the disposition of tolbutamide and lignocaine." Br J Clin Pharmacol 18 (1984): 853-60
Parker G, Ene MD, Daneshmend TK, Roberts CJ "Do beta blockers differ in their effects on hepatic microsomal enzymes and liver blood flow?" J Clin Pharmacol 24 (1984): 493-9
Bax ND, Tucker GT, Lennard MS, Woods HF "The impairment of lignocaine clearance by propranolol: major contribution from enzyme inhibition." Br J Clin Pharmacol 19 (1985): 597-603
Conrad KA, Byers JM, Finley PR, Burnham L "Lidocaine elimination: effects of metoprolol and of propranolol." Clin Pharmacol Ther 33 (1983): 133-8
Schneck DW, Luderer JR, Davis D, Vary J "Effects of nadolol and propranolol on plasma lidocaine clearance." Clin Pharmacol Ther 36 (1984): 584-7
Jordo L, Johnsson G, Lundborg P, Regardh CG "Pharmacokinetics of lidocaine in healthy individuals pretreated with multiple doses of metoprolol." Int J Clin Pharmacol Ther Toxicol 22 (1984): 312-5
Ochs HR, Skanderra D, Abernethy DR, Greenblatt DJ "Effect of penbutolol on lidocaine kinetics." Arzneimittelforschung 33 (1983): 1680-1

InnoPran XL

Generic Name: propranolol

Brand name: Hemangeol, Inderal LA, Inderal XL, InnoPran XL, Inderal, InnoPran XL

Synonyms: n.a.

What is InnoPran XL?

Lidocaine injection

Generic Name: lidocaine

Brand name: UAD Caine, Xylocaine HCl, Xylocaine-MPF, Lidoject 1, Xylocaine Dental Cartridges, Lidoject 2, Xylocaine Duo-Trach Kit, Xylocaine HCl For Spinal, L-Caine, Dilocaine, Nervocaine, Truxacaine, Anestacaine

Synonyms: Lidocaine (Systemic)

What is Lidocaine injection?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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