InnoPran XL and Maxalt-MLT

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using rizatriptan together with propranolol may increase the effects of rizatriptan. Contact your doctor if you experience severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure (convulsions), neck stiffness, tiredness, lack of coordination, feeling light-headed, or fainting. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSE: Coadministration with propranolol may increase the plasma concentrations of rizatriptan. The exact mechanism is unknown but may involve propranolol inhibition of rizatriptan metabolism via monoamine oxidase, subtype A. In 11 healthy subjects, propranolol (120 mg orally every 12 hours for 7 days) increased the mean peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of rizatriptan (10 mg single dose) by 75% and 67%, respectively, compared to placebo. A 4-fold increase in rizatriptan AUC was observed in one case. In 20 healthy subjects, reducing the dosage of propranolol (60 mg twice daily for 7 days) and/or staggering the time of administration (1 to 2 hours) lessened somewhat but did not eliminate the effect on rizatriptan pharmacokinetics. In contrast, 25 healthy subjects given a single 10 mg dose of rizatriptan following nadolol (80 mg every 12 hours) or metoprolol (100 mg every 12 hours) for 7 days demonstrated no evidence of a significant pharmacokinetic interaction. No adverse effects were attributed to any of the drug combinations in the studies, and no effect on the active N-monodesmethyl metabolite of rizatriptan was reported.

MANAGEMENT: Caution is advised if rizatriptan must be used with propranolol. Patients treated with propranolol should not receive greater than 5 mg of rizatriptan as a single dose, nor more than a maximum of 3 doses in any 24-hour period. It appears that the full range of rizatriptan dose may be used during coadministration with atenolol, metoprolol, nadolol, or timolol.

InnoPran XL

Generic Name: propranolol

Brand name: Hemangeol, Inderal LA, Inderal XL, InnoPran XL, Inderal, InnoPran XL

Synonyms: n.a.

What is InnoPran XL?

Maxalt-MLT

Generic Name: rizatriptan

Brand name: Maxalt, Maxalt-MLT

Synonyms: n.a.

What is Maxalt-MLT?