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InnoPran XL and Nebivolol and valsartan

Determining the interaction of InnoPran XL and Nebivolol and valsartan and the possibility of their joint administration.

Check result:
InnoPran XL <> Nebivolol and valsartan
Relevance: 11.01.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

If you are receiving valsartan and propranolol together with a medication called an ACE inhibitor, you should talk to your doctor to make sure this treatment is appropriate for your condition. When used in the treatment of heart failure, this three drug combination has been associated with increased side effects and an increased rate of death. The reason for this is not clear. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: In the Valsartan Heart Failure Trial, the combination of valsartan with a beta-blocker and an ACE inhibitor was associated with unfavorable outcomes on morbidity and mortality in heart failure patients. The mechanism is unknown.

MANAGEMENT: The manufacturer recommends that the triple combination of valsartan with a beta-blocker and an ACE inhibitor be avoided in heart failure patients.

References
  • Cerner Multum, Inc. "Australian Product Information." O 0
  • Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
InnoPran XL

Generic Name: propranolol

Brand name: Hemangeol, Inderal LA, Inderal XL, InnoPran XL, Inderal, InnoPran XL

Synonyms: n.a.

Nebivolol and valsartan

Generic Name: nebivolol / valsartan

Brand name: Byvalson

Synonyms: Nebivolol and Valsartan

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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