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InnoPran XL and Pronestyl

Determining the interaction of InnoPran XL and Pronestyl and the possibility of their joint administration.

Check result:

InnoPran XL <> Pronestyl

Relevance: 11.01.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Some oral beta-blockers may decrease the clearance and increase the serum half-life of procainamide. Increased procainamide half-life and/or serum levels may result. The mechanism and clinical significance of this effect are unknown. Data are available for metoprolol and propranolol only and have been conflicting. If procainamide levels are elevated, reduction either of the beta-blocker dosage or of the procainamide dosage may be considered.

References

Dorian P, Newman D, Berman N, Hardy J, Mitchell J "Sotalol and type IA drugs in combination prevent recurrence of sustained ventricular tachycardia." J Am Coll Cardiol 22 (1993): 106-13
Ochs HR, Carstens G, Roberts GM, Greenblatt DJ "Metoprolol or propranolol does not alter the kinetics of procainamide." J Cardiovasc Pharmacol 5 (1983): 392-5

InnoPran XL

Generic Name: propranolol

Brand name: Hemangeol, Inderal LA, Inderal XL, InnoPran XL, Inderal, InnoPran XL

Synonyms: n.a.

What is InnoPran XL?

Pronestyl

Generic Name: procainamide

Brand name: Pronestyl, Procan SR, Pronestyl-SR, Procanbid

Synonyms: Pronestyl (injection)

What is Pronestyl?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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