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InnoPran XL and Propafenone Hydrochloride

Determining the interaction of InnoPran XL and Propafenone Hydrochloride and the possibility of their joint administration.

Check result:

InnoPran XL <> Propafenone Hydrochloride

Relevance: 11.01.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using propranolol and propafenone together can lower your blood pressure and slow your heart rate. This can cause a slow heartbeat, headaches, arrhythmias, mental status changes, dizziness, or feeling like you might pass out. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment or need your blood pressure checked more often if you take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Propafenone may significantly increase serum levels and effects of some oral beta-blockers. The proposed mechanism is inhibition of CYP450 2D6 first-pass metabolism and decreased hepatic clearance. Data are available for metoprolol and propranolol only; however, other hepatically metabolized oral beta-blockers may also be affected. Renally excreted beta-blockers such as atenolol, carteolol, nadolol, or sotalol are not expected to interact. In addition, negative inotropic effects may be potentiated.

MANAGEMENT: Patients receiving this combination should be monitored for hypotension, heart failure, bradycardia, arrhythmias, and mental status changes. Beta-blocker dosage may be decreased if necessary.

References

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InnoPran XL

Generic Name: propranolol

Brand name: Hemangeol, Inderal LA, Inderal XL, InnoPran XL, Inderal, InnoPran XL

Synonyms: n.a.

What is InnoPran XL?

Propafenone Hydrochloride

Generic Name: propafenone

Brand name: Rythmol, Rythmol SR

Synonyms: Propafenone

What is Propafenone Hydrochloride?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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