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InnoPran XL and Propylthiouracil

Determining the interaction of InnoPran XL and Propylthiouracil and the possibility of their joint administration.

Check result:

InnoPran XL <> Propylthiouracil

Relevance: 11.01.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using propranolol together with propylthiouracil may alter the effects of propranolol. Contact your doctor if you experience increase side effects such as uneven heartbeats, shortness of breath, dizziness, weakness, or fainting. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: The clearance of some beta-blockers with high extraction ratios may be reduced when a euthyroid state is achieved after the addition of antithyroid agents. Sotalol, nadolol, carteolol, and atenolol, which are primarily eliminated by the kidney, do not appear to be affected by changes in thyroid function.

MANAGEMENT: The patient should be closely monitored for altered efficacy and safety while achieving a euthyroid state or when the antithyroid agent dosage is added, discontinued, or changed. Beta blocker dose reductions may be required.

References

Aro A, Anttila M, Korhonen T, Sundquist H "Pharmacokinetics of propranolol and sotalol in hyperthyroidism." Eur J Clin Pharmacol 21 (1982): 373-7
Hallengren B, Nilsson OR, Karlberg BE, Melander A, Tegler L, Wahlin-Boll E "Influence of hyperthyroidism on the kinetics of methimazole, propranolol, metoprolol and atenolol." Eur J Clin Pharmacol 21 (1982): 379-84
Feely J, Stevenson IH, Crooks J "Increased clearance of propranolol in thyrotoxicosis." Ann Intern Med 94 (1981): 472-4
Feely J, Crooks J, Stevenson IH "Plasma propranolol steady state concentrations in thyroid disorders." Eur J Clin Pharmacol 19 (1981): 329-33
Feely J, Crooks J, Stevenson IH "The influence of age, smoking and hyperthyroidism on plasma propranolol steady state concentration." Br J Clin Pharmacol 12 (1981): 73-8

InnoPran XL

Generic Name: propranolol

Brand name: Hemangeol, Inderal LA, Inderal XL, InnoPran XL, Inderal, InnoPran XL

Synonyms: n.a.

What is InnoPran XL?

Propylthiouracil

Generic Name: propylthiouracil

Brand name:

Synonyms: n.a.

What is Propylthiouracil?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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